Interplexus Seriphos Phosphorylated Serine, 100 Capsules

SKU# 642392250160

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Seriphos Phosphorylated Serine
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Product Highlights
  • Seriphos
  • Dietary Supplement
  • Phosphorylated Serine Adaptogen and Adrenal Support
SKU 642392250160
Quantity 100 Capsules 
Serving Size 1 Capsule
Servings Per Container 100
Directions Take 1 capsule with water 15 minutes before a meal or as directed.
Warnings If pregnant, consult your physician before using this or any other product. Milk, Soy, Egg & Wheat Free. Store in a cool, dry place, NOT to exceed 77°F. DO NOT USE IF SEAL IS BROKEN. KEEP OUT OF REACH OF CHILDREN.
Ingredients …for product label information including a complete list of ingredients, click all product images above.
Other Ingredients Proprietary Blend (Phosphorylated Serine/Ethanolamine), Cellulose.
Product Details

Seriphos ®

Basic Chemistry

Phosphatidyl Serine when consumed in food, for example egg yolks, or in a capsule provides about 20% of active Phosphorylated Serine. Each 100 mg of Phosphatidyl Serine yields about 20 mg of active Phosphorylated Serine following consumption. The bulk of the weight is derived from two fatty acids, RI & R2.

In the intestinal tract, the various enzymes (brush border and pancreatic) clip off the fatty acids, predominantly the unsaturated fatty acids. These fatty acids are not reassembled in the body to the stump molecule, rather different fatty acids are attached by the body to replace RI and R2.

The shaded glycerol molecule is very abundant in the body because it is found in all body fat and in dietary fats/oils.

In brief, the Phosphatidyl Serine acts as a precursor molecule and is not the active form of this nutrient. In Interplexus tissues, the rate limiting step is the phosphorylation of the serine molecule.

Phosphatidyl Serine

In contrast, Phosphorylated Serine (brand name, SERIPHOS®) provides the activated or Phosphorylated Serine in a chelate form of magnesium and calcium.

In the local tissue, the Phosphorylated Serine is linked to glycerol and the appropriate fatty acids specific to each tissue, and is not linked to the fatty acids provided in the precursor Phosphatidyl Serine.

Phosphorylated Serine is a pure product not derived from animal tissue. The serine is from vegetable sources and the phosphate is from a pure phosphate donor compound.

Excerpts & Abstracts on the Use of Phosphorylated Serine


The early cortisol escape phenomenon observed after administration of 1 mg of dexamethasone in 50% of the elderly subjects in the study was reversed by two months therapy with Phosphatidyl Serine (PS), 3 x100 mg tablets daily.

An action of the compound at the neurotransmitter level is hypothesized.

A number of alterations of the **HPAA was detectable in the Interplexus study in normal elderly subjects; abnormal elevation of basal morning cortisol values (3 subjects); disruption of the circadian cortisol pattern (4 subjects); early cortisol escape phenomenon observed in seven of the subjects. A true nonsuppression was visible only in two individuals. Therefore, the early cortisol escape phenomenon appears to be the most consistent abnormality found in the subjects.

The question of contribution of non-specific stress factors to cortisol hypersecretion obviously cannot be ruled out. However, in Interplexus's opinion, an intrinsic neuro-endocrine disturbance, which may be part of a central dysfunction associated with aging, could be at the root of a substantial part of the hypersecretion.

According to the membrane hypothesis of aging, age-dependent changes of the membranes can negatively interfere with trophism of the neurons, with cell to cell communication and ultimately with neurotransmission and thus with most functions linked to neurotransmission, including hormonal secretion.

According to Massarotti, PS seems to stimulate some sort of morphogenetic neuronal plasticity, which acts as a compensatory adaptive mechanism to cell deterioration, and is capable of preventing or delaying the age dependent decline of neurotransmitter function. On the basis of Interplexus findings it can be speculated that existence of an analogous mechanism which acts on neurotransmission similar to that observed in animals treated with PS.

However, when considering the impairment of HPAA as a marker of a more central neurotransmitter imbalance, it can be supposed that the re-adjustment of such an altered parameter, although partial, may be brought about by some action at the neurotransmitter level.


Interplexus treated 149 patients meeting criteria of age associated memory impairment (AAMI) for 12 weeks with a formulation of Phosphatidyl Serine (100-150mg PS bid) or placebo.

Patients treated with the compound improved, relative to those untreated, with learning and memory tasks of daily life.

Analysis of clinical subgroup suggested that persons within the sample who performed at a relatively low level prior to treatment were most likely to respond to PS. Within this subgroup, there was improvement on both computerized and standard neuropsychological performance tests, and also on clinical global ratings of improvement. The results suggest that the compound may be a promising candidate for treating memory loss in later life.

Seriphos Phosphorylated Serine Brand: Interplexus

Rating: 4 stars, based on 1 review(s).
Price: $20.99 - Out of stock
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Interplexus Seriphos Phosphorylated Serine, 100 Capsules Reviews Showing 1 out of 1 reviews for Interplexus Seriphos Phosphorylated Serine, 100 Capsules


Seriphos Phosphorylated Serine review posted by aja  on 6/24/11

In large qty help raised my serotonin levels during recovery. unfortunate had to result to scrip but still use in my daily supplement program

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