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6/4/12 11:00 AM Comments

What is it? African Mango is a rare fruit that can be found in parts of Cameroon, Africa. Africans have been using the African mango and its seeds for hundreds of years, they call the seeds ‘Dikka Nuts’ and the extract ‘Irvingia Gabonesis.’ Natives believe that both the seeds and the extract have medicinal benefits beyond its weight loss capabilities.

 

How does it work in the body? The high soluble fiber content of the seeds can help keep cholesterol levels in an already normal, healthy range. It can bind bile acids in the gut, stopping re-absorption and causing conversion of more cholesterol to bile acids. Preliminary research indicates that extract from the seeds (Irvingia gabonensis) may inhibit the formation of fat. The extract is also thought to increase secretion of adiponectin by fat cells (adipocytes). Adiponectin plays a role in utilizing fats as a source of fuel, and its levels are correlated with a lower body fat percentage. When humans were given 150 mg of a standardized seed extract (IGOB131) of Irvinga gabonensis twice daily for 10 weeks it lead to healthy weight loss. The seeds may help keep blood sugar levels in a normal healthy range.

 

How do you take? Take one (1) capsule twice daily with or without food. This product is sold individually or in combination with other nutrients for supporting healthy weight management.

 

What is available? Life Extension, Integra-Lean Irvingia, 150 mg, 60 Vegetarian Capsules and Right Way Nutrition, African Mango Edge Diet, 60 Capsules.

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John K.

posted on Monday, June 18, 2012 3:30:34 PM America/Los_Angeles
@Julie- The two a day dosing of 150 mg for African mango seed extract is based on a double-blind placebo-controlled clinical study. See the abstract below for details. Life extension is using the certified invingia authentic supplement at 150 mg 2 times per day. Abstract BACKGROUND: A recent in-vitro study indicates that IGOB131, a novel seed extract of the traditional West African food plant Irvingia Gabonensis, favorably impacts adipogenesis through a variety of critical metabolic pathways including PPAR gamma, leptin, adiponectin, and glycerol-3 phosphate dehydrogenase. This study was therefore aimed at evaluating the effects of IGOB131, an extract of Irvingia gabonensis, on body weight and associated metabolic parameters in overweight human volunteers. METHODS: The study participants comprised of 102 healthy, overweight and/or obese volunteers (defined as BMI greater than 25 kg/m2) randomly divided into two groups. The groups received on a daily basis, either 150 mg of IGOB131 or matching placebo in a double blinded fashion, 30-60 minutes before lunch and dinner. At baseline, 4, 8 and 10 weeks of the study, subjects were evaluated for changes in anthropometrics and metabolic parameters to include fasting lipids, blood glucose, C-reactive protein, adiponectin, and leptin. RESULTS: Significant improvements in body weight, body fat, and waist circumference as well as plasma total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin and leptin levels were observed in the IGOB131 group compared with the placebo group. CONCLUSION: Irvingia gabonensis administered 150 mg twice daily before meals to overweight and/or obese human volunteers favorably impacts body weight and a variety of parameters characteristic of the metabolic syndrome. This is the first double blind randomized placebo controlled clinical trial regarding the anti-obesity and lipid profile modulating effects of an Irvingia gabonensis extract. The positive clinical results, together with our previously published mechanisms of gene expression modulation related to key metabolic pathways in lipid metabolism, provide impetus for much larger clinical studies. Irvingia gabonensis extract may prove to be a useful tool in dealing with the emerging global epidemics of obesity, hyperlipidemia, insulin resistance, and their co-morbid conditions SOURCE: Lipids Health Dis. 2009 Mar 2 IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation. SourceLaboratory of Nutrition and Nutritional Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon. jlngondi@yahoo.com

Julie

posted on Monday, June 18, 2012 3:21:51 PM America/Los_Angeles
I'm on my third bottle of the Life Extension product. I haven't noticed any benefit. Of course, I haven't had my cholesterol levels checked within that time. I do find it interesting, though, that the commercially-available African mango products do not follow the three a day dosing schedule that the study found to be effective for weight loss. I wonder why they would arbitrarily decide to alter the dosing schedule and potency without performing additional human trials to determine the effectiveness of a two-a-day dosing schedule.

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